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2 edition of Genetic Control of Natural Resistance to Infection and Malignancy (Perspectives in Immunology) found in the catalog.

Genetic Control of Natural Resistance to Infection and Malignancy (Perspectives in Immunology)

Emil Skamene

Genetic Control of Natural Resistance to Infection and Malignancy (Perspectives in Immunology)

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  • 11 Currently reading

Published by Academic Press Inc.,U.S. .
Written in English


The Physical Object
Number of Pages598
ID Numbers
Open LibraryOL7329032M
ISBN 100126476802
ISBN 109780126476804

There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models can simultaneously accommodate the inherent individual Cited by:


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Genetic Control of Natural Resistance to Infection and Malignancy (Perspectives in Immunology) by Emil Skamene Download PDF EPUB FB2

Genetic Control of Natural Resistance to Infection and Malignancy is a collection of papers presented at the Proceedings of an International Symposium of the Canadian Society for Immunology held in Montreal, Quebec. It provides information about the different models of genetic resistance to various diseases.

Miscellaneous: Genetic control of natural resistance to infection and malignancy. pp ref.9 Abstract: The genetic control of resistance to Rickettsia tsutsugamushi infection was analysed based on the responses to infection of the F 1 s, F 2 s and backcrosses from matings of BALB/c (resistant) and C3H/He (susceptible) mice mice Cited by: 7.

In: Genetic control of natural resistance to infection and malignancy. Academic, New York Google Scholar Cinader B, Dubliski S, Wardlaw AC () Distribution, inheritance, and properties of an antigen, MuBl, and its relation to hemolytic by: One of the fundamental observations made by Bang and co-workers some thirty years ago was that MHV infection of the host proceeds in a series of stages, which can be seen as three sequential barriers of host resistance 1–3.

These stages have also become the key to dissecting the genetic control of host resistance to by: 1. O’Brien AD, Rosenstreich DL, Metealf ES, Scher I () Differential sensitivity of inbred mice to Salmonella typhimurium: A model for genetic regulation of innate resistance to bacterial infection.

In: Skamene E (ed) Perspectives in immunology: Genetic control of natural resistance to infection and by: Genetics and Breeding for Disease Resistance of Livestock is a solid resource that combines important information on the underlying genetic causes and governing factors for disease resistance in food animals and applications for breeding purposes.

It describes genomics at each species level to help researchers and students understand disease. "The Symposium on Genetic Control of Natural Resistance to Infection and Malignancy, which formed the basis of this volume, was held under the auspices of the Montreal General Hospital Research Institute."--P.

xxi. An international symposium of the Canadian Society for. While quantitative genetic studies typically consider survival as an indicator for disease resistance (an individual’s propensity to avoid becoming infected or diseased), mortality rates of Cited by: 5.

Tuberculosis remains an important bacterial disease responsible for more than one million deaths per year. The risk of overt Genetic Control of Natural Resistance to Infection and Malignancy book is highest in the first year post infection, nevertheless, asymptomatic chronic infection (referred to as Latent Tuberculosis Infection, LTBI) may also be established.

LTBI cannot be ascertained directly, it can only be inferred from a skin or blood test of. Natural resistance to infection with several intracellular pathogens - both bacterial and protozoal - has recently been demonstrated to be under genetic control.

The ability of genetically-resistant mouse strains to prevent growth, in the reticuloendothelial tissues, of Mycobacterium bovis (BCG) is controlled by a single, dominant, autosomal Cited by: 3. Natural resistance of mice to infections with Salmonella typhimurium and Leishmania donovani is regulated by chromosome 1 gene(s) designated Ity and Lsh, respectively1,2.

Given the fact that these Cited by: Genetic factors play a key role in host response, disease severity, and ultimate outcome of infection with Mycobacterium tuberculosis in humans. In the mouse, the DBA/2J strain is very susceptible Cited by: Discover the best Drug Resistance books and audiobooks.

Learn from Drug Resistance experts like Elsevier Books Reference and Elsevier Books Reference. Read Drug Resistance books like Genetic Control of Natural Resistance to Infection and Malignancy and Drug Resistance As a Biochemical Target in Cancer Chemotherapy for free with a free day trial.

The most important genetic factor related to natural resistance to HIV-1 infection is the presence of the ∆32 mutation in the CCR5 gene. This mutation occurs in approximately 10% of Caucasian individuals and represents a deletion of 32 bp resulting in the synthesis of a truncated protein with only 4 of the 7 transmembrane domains required for protein expression at the cell surface [ 10 ].Cited by: Natural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma­ lignancy.

Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated.

Genetic control of natural resistance to infection and malignancy. New York, N.Y.: Academic Press, (OCoLC) Online version: International Symposium on the Genetic Control of Natural Resistance to Infection and Malignancy ( Montréal, Québec).

Genetic control of natural resistance to infection and malignancy. Genetic control of tuberculosis infection. There is no direct test for infection with M.

tuberculosis and the phenotype of M. tuberculosis infection is inferred exclusively from quantitative measurements of antimycobacterial immunity.

These assays cannot distinguish a possible anamnestic response to M. tuberculosis from persistent infection with the by: International Symposium on the Genetic Control of Natural Resistance to Infection and Malignancy ( Montréal, Québec).

Genetic control of natural resistance to infection and malignancy. New York, N.Y.: Academic Press, (DLC) (OCoLC) Material Type: Conference publication, Document, Internet resource: Document Type.

Genetic Approaches to the Study of Disease Resistance: With Special Emphasis on the Use of Recombinant Inbred Mice D. Briles, W. Benjamin Jr., W. Huster, B. Posey Pages Human resistance to infectious diseases is often regulated by multiple genes that control different aspects of host-parasite interaction.

Genetically distinct inbred strains of mice that differ in their susceptibility to specific pathogens are invaluable for dissecting such complex patterns and have allowed the identification of several host-resistance loci that regulate natural and acquired Cited by: Get this from a library.

Genetic Control of Natural Resistance to Infection and Malignancy. [Emil Skamene] -- Genetic Control of Natural Resistance to Infection and Malignancy.

Genetic control of Leishmania populations within the host. Genetic control of acute susceptibility of mice to L. donovani infection. Clin Exp Immunol ; – CASCited by: Despite traditional disease control measures, losses attributable to infectious diseases continue to impede the livestock industries.

An alternative approach to this problem is genetic disease resistance involving both immune and non-immune mechanisms, which is the inherent capacity of a previously. Genetic control of host resistance to infection and malignancy. New York: Liss, © (OCoLC) Online version: Genetic control of host resistance to infection and malignancy.

New York: Liss, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Emil Skamene. EXPERIMENTAL PARAS1TOL () Trypanosoma congolense: Genetic Control of Resistance to Infection in Mice MARGARET PINDER Centre de Recherches sur les Trypanosomoses Animales (CRTA), B.P.Bobo-Dioulasso, Republic of Upper-Volta, West Africa (Accepted for publication 5 December ) PINDER, M.

Cited by: Infections have long been thought to exert natural selection on humans. Infectious disease resistance is frequently invoked as a mechanism shaping human genetic diversity, but such hypotheses have rarely been quantitatively evaluated with direct measures of disease-related mortality.

Enhancement of genetically determined resistance to tuberculosis by natural selection has been Cited by: Salmonellosis is a frequent disease in poultry stocks, caused by several serotypes of the bacterial species Salmonella enterica and sometimes transmitted to humans through the consumption of contaminated meat or eggs.

Symptom-free carriers of the bacteria contribute greatly to the propagation of the disease in poultry stocks. So far, several candidate genes and quantitative trait loci (QTL Cited by: Ity, a gene controlling natural resistance to Salmonella typhimurium infection 1,2, and Lsh, which controls innate resistance to Leishmania donovani infection 3, are both located on chromosome 1 Cited by: Genetic control of systemic Leishmania major infections: dissociation of intrahepatic amastigote replication from control by the Lsh by: Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial.

Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have Cited by: Perhaps the most well known resistance is that which is provided by sickle-cell anemia to malaria.

Malaria is one of the leading causes of death in the global human population, with million people infected and two million people dying of it per year [10].Sickle-cell anemia is a genetic condition that results in misshapen red blood cells, and the crescent-shape helps prevent the malaria.

Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro. S Yoshida, Y Goto, Y Mizuguchi, K Nomoto, and E Skamene Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, by: Genetic Control of the Susceptibility to Bacterial Infection Genetic Control of the Susceptibility to Bacterial Infection.

Editors: Briles, David E. (Ed.) Free Preview. Buy this book eBook Genetic Approaches to the Study of Disease Resistance: With Special Emphasis on the Use of Recombinant Inbred Mice. Pages ISBN: OCLC Number: Description: xi, pages: illustrations ; 25 cm.

Contents: Genetic control of the susceptibility to infection with pathogenic bacteria / J.B. Zabriskie and A. Gibofsky --Genetic approaches to the study of disease resistance / D.E. Briles [and others] --Influence of host genes on resistance of inbred mice.

Misuse of antibiotics, such as prescribing them for non-bacterial infections (colds, influenza, most upper respiratory infections, etc.) or prescribing the "newest" antibiotic on the market when older brands may still be as effective simply inceases the rate at which this natural selection for resistance occurs.

Inbred mouse strains differ in their resistance to infection with the human pathogen Trypanosoma rhodesiense.

Of the strains tested, C57BL/6 (B6) mice were the most resistant, and BALB/c (C) mice. natural resistance to systemic disease with severalunrelated intracellular pathogens: Salmonella typhimurium (13, 14, 19), Mycobacterium bovis BCG (7), Mycobacterium lepraemurium (17), Mycobacterium intracellulare (6), and Leishmania donovani (3).

TheLsh gene product acts in the acute phase of infection to limit the proliferation of theseCited by: v ol. 69, genetic resistance in s.

pneumoniae infection median survival times were seen (Fig. 1), correlating with the number of pneumococci in the blood 24 h postinfection (Fig. Human genetic resistance to malaria refers to inherited changes in the DNA of humans which increase resistance to malaria and result in increased survival of individuals with those genetic changes.

The existence of these genotypes is likely due to evolutionary pressure exerted by parasites of the genus Plasmodium which cause malaria. Since malaria infects red blood cells, these genetic changes.

Abstract. The natural resistance–associated macrophage protein 1 (NRAMP1) is implicated in the pathophysiology of mycobacterial infections. We investigated by polymerase chain reaction previously published Nramp1 genotypes at 4 loci—INT4, ND, 3′UTR, and 5′(CA) n microsatellite markers—in human immunodeficiency virus–negative patients with tuberculosis and healthy control Cited by:.

Genetic Control of Natural Resistance to Infection and Malignancy Author Elsevier Books Reference Vaccine free Healthy in a Viral Epidemic How to Prevent Virus Infections Vaccine-Free with Three Effective Antiviral Strategies.News update, July The risk posed by using antibiotics in livestock is a global one, according to recent news.

In May, researchers announced the first case of a patient in the United States infected with bacteria resistant to a so-called "treatment of last resort" — an antibiotic reserved for certain, unusually dangerous infections.The concept that susceptibility and resistance to infectious diseases is genetically determined has been established for more than 20 years, and genetic regulation of host responsiveness to C.

albicans infection is neither novel nor unexpected. Nevertheless, many published models of the disease have failed adequately to consider the effect of Cited by: